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F.D.A. Approves New Nasal Spray for Migraines

The FDA has approved a nasal spray for treatment of migraines that uses a different therapy from other nasal products on the market for severe headache pain. The drug, called zavegepant, performed better than a placebo in relieving pain and patients’ most bothersome symptoms.

1 min read
  • FDA has approved a Pfizer nasal spray for treatment of migraines called zavegepant, marketed as Zavzpret.
  • In a clinical trial of 1,269 patients, 24% of those taking the medication reported freedom from pain compared to 15% who took a placebo.
  • It's the first and only nasal spray for migraines to block the release of proteins called calcitonin gene-related peptides.
  • Nasal sprays are absorbed more quickly than pills, with some side effects like altered sense of taste, nasal discomfort and nausea reported.
  • It's safe for patients who have had a heart attack or a stroke.
F.D.A. Approves New Nasal Spray for Migraines
Pfizer’s treatment applies an approach that is different from some other products, which doctors say may make it safer for people at risk of heart attacks or stroke.
The New York TimesBy Christina Jewett

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